Scientist - Bioprocess Development

Responsibilities:

• Design and set up a bioreactor lab, including coordinating with vendors to qualify and procure bioreactors and supporting equipment
• Perform experimental screening of bioprocess approaches at bench-scale to establish optimal processes and operating modes in line with future commercialization targets
• Develop robust, iterative scale-down processes to maximize yield and process efficiency at benchtop (<10L) scale
• Define key process parameters for scale-up and develop analytical methods for continuous process monitoring and control
• Collaborate with other teams and members of the bioprocess group on the development and implementation of robust and scalable bioprocesses for pilot production and technology transfer for GMP manufacturing
• Align with senior leadership to implement critical decisions
• Lead co-development partnerships to drive shared process development goals
• Conduct rigorous experimental design, documentation, and data analysis 
• Provide concise and effective reporting on project deliverables and presentation of data
• Evaluate processes and assumptions for potential improvements to efficiency and manufacturability, providing creative solutions to challenging technical problems

Requirements:

• M.S. or PhD in a relevant field (Bioengineering, Chemical Engineering, Cell Biology, or equivalent
• 5+ years of industry experience (MS) or 3+ years of industry experience (PhD) in biotechnology, cell manufacturing or a relevant engineering field
• 2+ years of direct experience in lab to mid-scale (50-500L) animal cell culture in a process development environment
• Experience with batch and fed-batch cell culture is essential; intensified or continuous process experience is a plus
• Tech transfer experience is preferred
• Experience with scale-down model development, predictive modeling, and model validation is a plus
• Experience with high throughput bioreactor systems and automation is a plus
• Track record of successfully leading small teams is strongly preferred
• Strong track record of peer-reviewed publications is preferred
• Demonstrated scientific rigor toward continuous improvement
• Proficiency with Design of Experiments (DOE) methodology for bioprocess development, including experiment design and data analysis
• Proficiency in engineering techniques, including quantitative modeling and mass balance
• Basic scripting in relevant languages such as Python, R, SQL, etc.
• Familiarity with mammalian metabolic pathways and proficiency in metabolic flux analysis is a plus
• Understanding of a range of analytical chemistry techniques necessary to support process development
• Ability to work in a fast-paced, dynamic environment and skills to prioritize and deliver against timelines
• Strong troubleshooting and problem-solving skills
• Excellent written and verbal communication skills, including strong command of the English language